In the ever-evolving landscape of health and wellness, a new challenge has emerged for those using medical weight management approaches: maintaining precious muscle mass while shedding unwanted pounds. Society’s been given some new tools for the latter, and now it’s ever more important to focus on the former — keeping that lean muscle!
The Vitamin Shoppe GLP-1 Support Protein Powder with myHMB® helps preserve muscle during weight loss with 30g protein per serving. Perfect for maintaining lean tissue while achieving body composition goals!
The Vitamin Shoppe has stepped up to address this specific need with their GLP-1 Support Protein Powder from their Whole Health RX line, featuring the clinically-backed myHMB® technology from TSI Group.
This dietitian-formulated, doctor-approved supplement is designed to work alongside medical weight management protocols (although they aren’t necessary to enjoy the product), helping users maintain the muscle they’ve worked hard to build while supporting healthy body composition changes.
With an impressive 30 grams of protein per serving and a host of specialized ingredients, including the anti-catabolic patented powerhouse myHMB combined with vitamin D3, GLP-1 Support Protein Powder targets the specific nutritional needs of those navigating aggressive weight management journeys – whether they’re medically-driven or not.
We get into the muscle-protective formula below, but first, see prices and sign up for PricePlow’s news alerts and check prices with the widget below:
When the body enters a caloric deficit, it doesn’t just burn fat—it can break down muscle tissue too. This creates a significant challenge for anyone looking to improve their body composition. Research shows that for every kilogram of weight lost during a caloric deficit, approximately one-third can come from muscle mass unless specific steps are taken to prevent it.
This muscle loss is more than just a cosmetic concern. Muscle tissue is metabolically active, burning calories even at rest. When muscle is lost during weight management, it can result in:
For those using medical weight management approaches, these concerns become even more pressing, as the accelerated weight loss can sometimes lead to greater muscle breakdown without proper nutritional support.
Each serving provides the following, all combined totaling 30 grams of protein from multiple sources below:
Protein Blend (Whey protein isolate, whey protein concentrate)
The Vitamin Shoppe leverages a strategic whey protein blend combining whey protein isolate and whey protein concentrate. This combination isn’t just about hitting a protein target, it’s a scientifically-backed approach to supporting body composition during weight management.
Why Whey Protein Matters for Weight Management
Multiple meta-analyses repeatedly demonstrate whey protein’s incredible potential in body composition transformation. Research shows that whey protein supplementation can be a game-changer for individuals looking to manage their weight effectively.[1]
Key Benefits Backed by Research
- Fat Mass Reduction: Studies consistently show whey protein can significantly decrease body fat, especially in younger individuals and those engaging in regular physical activity.[2] The combination of whey isolate and concentrate provides a well-rounded protein source that supports this fat-loss mechanism.
- Lean Mass Preservation: Perhaps most importantly for weight management, whey protein helps preserve lean muscle mass during caloric restriction (and may potentially help the body increase it as well).[3] This is crucial because muscle tissue is metabolically active, helping to maintain a higher resting metabolic rate.
The Isolate and Concentrate Advantage
The blend of whey protein isolate and concentrate offers unique benefits:
- Whey Protein Isolate: Typically higher in protein content and lower in fat and lactose
- Whey Protein Concentrate: Provides additional nutrients and a more complete amino acid profile
Whey protein can stimulate muscle protein synthesis more effectively than other protein sources, making it an ideal component in a supplement like this one for those seeking to maintain muscle when dieting.[4]
More Than Just Protein
In this product, the whey protein blend works synergistically with other ingredients like myHMB® and PeptiStrong®, creating a wider-scale approach to supporting healthy body composition… this isn’t just a standard protein powder! The protein isn’t just about quantity, but about providing the right nutritional support during weight management journeys.
While the exact ratio of isolate to concentrate isn’t specified, and we’re not sure how much of the 30 grams of protein comes from each ingredient in the supplement, the overall protein blend represents a science-backed approach to nutritional support during weight management. This all leads to helping users maintain muscle, support metabolism, and achieve their body composition goals.
myHMB® (β-hydroxy-β-methylbutyrate) – 3g
Weight loss journeys often come with a major unintended consequence: muscle loss. This metabolic challenge can derail long-term health and fitness goals, making TSI Group’s myHMB® a critical ally in body composition management.[5]
The Metabolic Science of Muscle Protection
At its core, HMB is a metabolite of leucine (the primary branched-chain amino acid) that shows a smart approach to muscle preservation. HMB offers a scientifically validated mechanism that directly addresses muscle metabolism[6] during caloric restriction.
The supplement works through two primary metabolic pathways that are critical when dieting. First, HMB activates the mTOR pathway, a major signaling mechanism for muscle maintenance. And importantly in our situation, it significantly suppresses muscle protein breakdown through multiple complex metabolic routes.[7]
Real-World Evidence of Muscle Preservation
The practical implications of HMB become clear in studies examining challenging metabolic conditions. For instance, a study involving female judo athletes demonstrated HMB’s ability to maintain muscle mass during calorie-restricted diets.[8]
Additionally, there’s published research on middle-aged women, a population vulnerable to muscle loss over time and when dieting. A 12-week study revealed that in sedentary participants, HMB not only maintained arm lean mass but also increased thigh muscle volume![9]
Beyond Muscle: Metabolic Composition Changes
HMB’s impact on body composition beyond mere muscle preservation is also worth noting. Research has shown that it can simultaneously support fat loss while protecting lean mass, often considered a “holy grail” for dieters.[10]
In the 12-week study on middle-aged women cited above, the researchers found that HMB has an incredible ability to reduce intramuscular adipose tissue (IMAT), a type of fat infiltration within muscle tissue that can compromise metabolic health. Think of this as the marbling of fat in the beef you eat — too much marbling is not healthy! The reduction occurred even in sedentary participants, suggesting that HMB has potential that extends far beyond standard muscle-building supplements.[9]
Optimal Dosage and Effectiveness
Read the full story in PricePlow’s main HMB Supplements article.
The sweet spot for HMB supplementation sits around 38 mg per kilogram of body weight daily. The 3g of myHMB® in this formula represents a clinically-studied dose designed to provide meaningful support for muscle preservation across diverse populations, as discussed in detail in the ISSN’s updated position stand on HMB.[5]
Synergy with Vitamin D3! (also in this protein)
Note that this protein also includes vitamin D3, and that’s not just to pretty up the label. Researchers have discovered an incredible synergy between HMB and vitamin D3 for muscle health.[11]
While the landmark study was conducted on older adults, its findings suggest potentially broader implications. In a 12-month randomized controlled trial, the research team found that participants receiving HMB and vitamin D3 experienced significant improvements in muscle function… even without exercise. The combination helped preserve muscle strength and leg torque, with the non-exercising group maintaining muscle capacity while the placebo group continued to lose it![11]
Getting after it this month? Then look beyond just protein powder and boost growth and recovery with BodyTech Elite Creatine + HMB, powered by myHMB!
A retrospective analysis also revealed that vitamin D status significantly impacts HMB’s effectiveness. Participants with adequate vitamin D levels experienced the most pronounced benefits, while those with low vitamin D saw minimal improvements.[12] This line of research underscores why combining HMB with vitamin D3 is a smart strategic approach to supporting muscle health across different populations.
So for this and so many other reasons, we always suggest getting enough sunshine and UV light, and to get vitamin D levels tested at least twice a year.
Summary: myHMB® is Smart Supplementation in the Era of GLP-1
Ultimately, for individuals navigating aggressive weight management protocols, myHMB® offers a scientifically-backed approach to muscle preservation. It’s more than a supplement… it’s a strategic tool for maintaining metabolic health, protecting hard-earned muscle, and supporting sustainable body composition changes.
You can read more about HMB in our article titled “HMB (β-hydroxy β-methylbutyrate): Performance-Driven Muscle Supplement“. There’s also another great option from The Vitamin Shoppe, BodyTech Elite Creatine + HMB.
PeptiStrong® (Fava Bean Protein Hydrolysate) – 2.4g
The Vitamin Shoppe’s GLP-1 Support Protein Powder also includes 2.4 grams of PeptiStrong, an innovative, AI-discovered ingredient derived from Vicia faba (fava bean) protein that helps address one of the biggest challenges during caloric restriction: muscle loss. This provides 2.4 grams of protein, but boosting the protein macronutrient number is not why it’s here:
How PeptiStrong Works
Unlike traditional protein supplements that simply provide amino acids, PeptiStrong is a peptide network that works by signaling multiple pathways to protect and enhance muscle tissue:
- Enhanced Protein Synthesis: PeptiStrong activates the mTOR pathway by increasing phosphorylation of S6 ribosomal protein, a key marker for muscle protein synthesis.[13]
- Reduced Inflammation: PeptiStrong contains bioactive peptides that decrease TNF-α secretion, helping to reduce inflammation that can contribute to muscle breakdown.[14]
- Decreased Muscle Wasting Signals: Research shows PeptiStrong can reduce the expression of genes linked to muscle atrophy like MuRF-1 and MAFbx/Atrogin-1.[13]
Clinically Supported Results
The above mechanisms are great, but even greater is that they work out in clinical research.
In a randomized, double-blind, placebo-controlled trial, subjects receiving PeptiStrong showed significantly improved strength recovery and reduced fatigue following intense exercise compared to placebo.[15]
Even more impressive? PeptiStrong also significantly suppressed plasma myostatin levels![15] This is crucial since myostatin acts as a “brake” on muscle growth.
The 2.4g dose in this formula is aligned with clinical research, ensuring you’re getting an effective amount to support muscle preservation during your weight management journey. By including PeptiStrong alongside myHMB and high-quality proteins, The Vitamin Shoppe has left no stone unturned in helping their customers maintain muscle mass during periods of caloric restriction or increased physical demands.
Bovine Collagen Peptides – 5g
We’re not done with protein yet. The inclusion of 5g of bovine collagen peptides also provides a few more amino acids that may not be ingested as copiously by dieters. While protein powders typically focus solely on muscle protein sources, this formula recognizes the broader potential of collagen in supporting soft tissue, which is just as important to maintain!
The ISSN’s updated position stand on HMB reinforces its role in muscle health and performance. Key findings show it’s safe, effective for muscle growth and recovery, and works best when timed around training. Best part? Benefits seen across all ages and fitness levels![16]
Collagen’s Role in Muscle and Metabolic Health
Collagen peptides have emerged as a promising supplement for dieters. Research suggests these peptides can play a crucial role in maintaining lean body mass and supporting metabolic function.[17]
Supporting Muscle Preservation
During periods of caloric restriction, maintaining muscle mass becomes challenging. Collagen peptides offer a unique amino acid profile (rich in glycine, proline, and hydroxyproline) that may help preserve muscle tissue and support recovery.[18]
Complementing Weight Management Goals
Beyond muscle support, collagen peptides have been associated with potential benefits in:
- Skin elasticity during weight loss
- Joint health during increased physical activity
- Supporting overall protein intake and satiety
More Than Just a Protein Source
We often see collagen in “hair, skin, and nails” formulas, but it doesn’t have to just be that way! The 5 grams in this formula works synergistically with whey proteins, myHMB®, and other ingredients to create a “total body” approach to body composition support. It’s not just about losing weight, but about maintaining health and function throughout the process.
Glutamic Acid – 5g
One of the standout ingredients in this formula is a substantial 5-gram dose of glutamic acid. While not commonly highlighted in protein supplements, this powerful amino acid deserves your attention, especially when you’re trying to maintain muscle during aggressive weight management.
Glutamic acid is a non-essential amino acid that plays crucial roles in nitrogen homeostasis and energy metabolism throughout the body.[19] If you’re familiar with glutamine (a common supplement staple), you should know that glutamic acid and glutamine are closely related: Glutamine is actually synthesized from glutamic acid in the body!
Why Glutamic Acid Matters for Muscle Preservation
During weight loss, maintaining nitrogen balance becomes especially critical for preserving muscle tissue. Here’s why the addition of glutamic acid is so valuable:
Metabolic Versatility
Glutamic acid serves as a key metabolic hub in skeletal muscle. It’s involved in both protein synthesis and energy production,[20] making it valuable during caloric restriction.
Supports Nitrogen Balance
As a primary carrier of nitrogen in the body, glutamic acid helps maintain positive nitrogen balance, which is essential for preserving lean muscle during weight loss.[19]
Muscle Amino Acid Transport
Recent research has shown that glutamic acid can enhance the expression of amino acid transporters in muscle tissue, potentially improving the delivery of other muscle-building amino acids.[21]
Glutamine Production
Glutamic acid serves as the direct precursor to glutamine, which has well-documented benefits for muscle preservation and recovery. By providing glutamic acid, this formula gives your body the raw material needed to produce glutamine internally.[22]
Synergistic Effects with Other Ingredients
Early preclinical research has found that combining glutamic acid with other amino acids like leucine (abundant in whey protein) can significantly enhance muscle protein synthesis pathways.[22]
The Flavor Factor (Bonus Benefit)
As an interesting side note, glutamic acid is related to glutamate – the compound responsible for the savory “umami” taste we love in foods. This may contribute to the excellent flavor profile of this product while delivering serious muscle-supporting benefits.[23]
Kudos to the team at The Vitamin Shoppe for bringing this one out — glutamic acid is a lesser-known gem that we had just begun digging into, and the research looks quite promising!
DigeZyme® Multi Enzyme Complex – 100mg
When you’re focused on body composition during weight management, protein absorption becomes critically important. That’s where DigeZyme comes in. This is a specialized multi-enzyme complex added to enhance the digestion and utilization of the formula’s impressive protein blend.
What is DigeZyme?
DigeZyme is a proprietary blend of five digestive enzymes: α-amylase, protease, cellulase, lactase, and lipase. Each enzyme targets specific macronutrients, breaking them down more efficiently to maximize nutrient absorption and reduce digestive discomfort.
How DigeZyme® Works for Muscle Preservation
Research shows that proteolytic enzymes like these can significantly improve the absorption rate of whey protein concentrate, making more amino acids available for muscle preservation.[24] This becomes especially valuable during caloric deficits, where every gram of protein counts.
Good to know, clinical studies have also demonstrated that enzyme supplementation can improve recovery after exercise by regulating inflammation.[25] This anti-inflammatory support complements the protein blend’s muscle-protective effects.
By enhancing protein utilization and supporting recovery, DigeZyme® helps ensure you’re getting the maximum benefit from every scoop of GLP-1 Support Protein Powder.
Vitamin D3 – 13mcg (520IU – 65% DV)
Touched upon above in the myHMB section, vitamin D3 plays a crucial role in muscle preservation and overall body composition, making it an ideal complement to the muscle-supportive ingredients in this protein powder — even without knowing the synergistic HMB research! Science has consistently demonstrated that vitamin D is essential for maintaining muscle strength and preventing muscle breakdown.[26]
Meanwhile, adequate vitamin D levels are associated with improved muscle function and reduced risk of muscle loss during weight management.[27] The 13mcg (520 IU) dose in this supplement provides meaningful support for maintaining muscle mass, but without going overboard, since excess vitamin D3 use can lead to soft tissue calcification.[28-32]
Beyond muscle health, vitamin D is well known to support overall metabolic function and immune system balance.[33]
The Vitamin Shoppe’s GLP-1 Support Protein is specifically designed for individuals on serious weight management protocols who want to maintain their muscle mass while achieving their health goals. It’s ideal for:
Technically speaking, we could make an argument that this product would be fantastic for those who are attempting to gain muscle mass, too. After all, just look at the ingredients inside!
To use, simply mix one scoop (46g) into 8-12 fl. oz. of water or your beverage of choice. The chocolate flavor offers an enjoyable way to support your muscle preservation goals.
Note that this is also non-GMO Project verified and formulated without gluten, soy, titanium dioxide, magnesium stearate, synthetic colors, flavors, or sweeteners.
The Vitamin Shoppe’s GLP-1 Support Protein Powder with myHMB represents a brilliant approach to a modern nutritional challenge. By combining clinically-studied ingredients like myHMB with high-quality protein sources and complementary nutrients, this formula offers very well-targeted support for maintaining muscle mass during those “seasons” of serious dieting.
Rather than focusing solely on the scale, this product helps shift the conversation toward healthy body composition, and it does that by leveraging protein and additional anti-catabolic, nitrogen-based ingredients. This helps preserve the metabolically active muscle tissue, supporting long-term success, which should be everyone’s goal.
For those navigating a new medical weight management journey, this formula provides an evidence-based tool to help maintain the muscle for lasting results and overall wellbeing. Color us impressed by The Vitamin Shoppe’s formulation squad here, this one gets high marks from us!
As always, you can check prices and stay updated on The Vitamin Shoppe’s innovative offerings with PricePlow:
